On irradiation, the arene ligand is lost and the coordinatively unsaturated complex, 111, is formed. The last step, the acetylation of salicylic acid, is tricky because for the production of bulk drugs, yield and purity are essential to achieve cost-effectiveness. Since the photolysis of η5-cyclopentadienyliron(II) salts produces a relatively weak iron-based Lewis acid, their reactivity as photoinitiators in cationic polymerization is lower than typical Brønsted superacid producing diaryliodonium and triarylsulfonium salts. Its use in paints, thinners, inks, adhesives, and rubbers, however, is decreasing and now accounts for less than 2% of current benzene production. Not to be overlooked, benzene also occurs naturally with sources being volcanoes, forest fires, and cigarette smoke. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. Skin sensitisation provides substance information on the substance’s sensitisation effect on the skin. Since the photolysis of η5-cyclopentadienyliron(II) salts produces a relatively weak iron-based Lewis acid, their reactivity as photoinitiators in cationic polymerization is lower than typical Brønsted superacid producing diaryliodonium and triarylsulfonium salts. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. Cumene is a common name for isopropylbenzene, an organic compound. No or insufficient data available at present, Hazard related to composition of atmosphere identified, No potential to cause toxic effects if accumulated (in higher organisms) via the food chain, bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day), DMEL (Derived Minimum Effect Level) - not included for short–term effects, Insufficient data available (further information necessary), Hazard unknown (no further information necessary), Hazard unknown but no further hazard information necessary as no exposure expected, ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added, Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian), No adverse effect observed (not irritating), Adverse effect observed (irreversible damage), mg/kg bw/day (nominal/actual dose received), See ‘Study results oral: Prioritization by test species’, mg/L air (combining mg/L air, mg/L air (nominal), mg/L air (analytical), mg/m³ air, mg/m³ air (nominal), mg/m³ air (analytical)), ppm (combine ppm, ppm (nominal), ppm (analytical), mg/kg bw/day (actual dose received), mg/kg bw/day (combining mg/kg bw/day (nominal), mg/kg bw/day (actual dose received) and mg/kg bw/day), mg/cm² per day (combining mg/cm² per day, mg/cm² per day (nominal), mg/cm² per day (analytical)), No study available / no study available (further information necessary). Phenol is produced from benzene using different routes, such as benzene to chlorobenzene and chlorobenzene to phenol, or benezene to isopropylbenzene (commonly called cumene) to phenol. Sulfamic acid,(1-methylethyl); The availability of additional data beyond the five results displayed is indicated by (…). From: Encyclopedia of Toxicology (Third Edition), 2014, S. Nikfar, A.F. It is obtained by fermentation (retains a lesser proportion of the acetone market) or chemical synthesis (either as a main product or as a by-product) mainly via the cumene process to produce phenol. If so, the data provided is not processed for the Brief Profile. Cumene hydroperoxide does not influence additionally to the initiation of oxidation. PNEC STP, data displayed in milligram per litre. The PIC regulatory processes identified for the Brief Profile are: The ’About this substance’ section provides an overview of the volume in which this substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). The data presented in these sections has been cleaned to remove names of one character or less, or names which consist solely of punctuation or numerical characters. Cumene is structurally a member of the alkyl aromatic family of hydrocarbons, which also includes toluene (methylbenzene) and ethylbenzene. This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, laboratory work, batch processing in synthesis or formulation with opportunity for exposure, calendering operations, transfer of substance into small containers, roller or brushing applications and treatment of articles by dipping and pouring. When submitted by the lead of a joint submission, the classifications may also reveal agreement between companies. Hence, its largest use is as a solvent in paint, varnishes, lacquers, plastics, and fibers, and a great variety of miscellaneous solvent uses (fats, oils). 0,3 en 0,8 vol%). For example, an update in a section of a dossier that is not displayed in the Brief Profile will not result in an update of the Brief Profile. For example CLH index numbers, CN numbers, deleted CAS numbers, etc. In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. isopropyl-sulfamic acid; Verder wordt het gebruikt voor de synthese van organische peroxiden, waaronder in de eerste plaats cumeenhydroperoxide, alfa-methylstyreen en propeenoxide. Chemically, aspirin is a very simple aromatic molecule with a benzene ring, a carboxylic acid group, and an acetate group (Figure 10.23). The availability of additional data beyond the five results displayed is indicated by (…). The % is based on count of values provided. Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight). The structure is a computer generated visualisation of the molecular structure derived from the InChI character string. The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, treatment of articles by dipping and pouring, roller or brushing applications, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and manual maintenance (cleaning and repair) of machinery. The antioxidant activities of 3-hydroxy-DBPs and the 3,8-dihydroxy-DBPs were demonstrated in vitro using five free radical scavenging assays. P A substantial amount of information exists on the compound’s potential threat to individuals who may become exposed to phenol in the workplace.